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Stem cell therapy has created a breakthrough in the treatment of various diseases. In this sense, explained how stem cells are used to treat arthritis and hardening of the advantages of this method compared to traditional surgical methods. Look.

Until recently, the arthritis can be treated either by the administration of drugs or performing surgery in chronic cases. Many people are being treated for a long time, and for some, the results are not very reliable. Nevertheless, the discovery of cell-based therapies, the place of treatment and technology have changed. Although an expensive treatment option may be to treat arthritis almost completely from their roots.

There are different types of arthritis, including rheumatoid arthritis is mainly treated cell therapy. Show synovial membrane lining of the tendons and joints become inflamed, resulting in even more pain, pain, stiffness and swelling in the joints. This is the general condition of rheumatoid arthritis. With the development of basic research and medical science, this therapy can cure inflammation. So, how is that possible? We explain this in the following paragraphs.

Stem cells for the treatment of arthritis

The clinical results

Arthritis is an autoimmune disease, because inflammation occurs when an active immune response against the body itself. Thus, antibodies present in the body, they begin to affect the cells and tissues, causing severe inflammation for them. In the case of rheumatoid arthritis, these antibodies are anti-MCV, rheumatoid factor (anti-IgGFc) and CSLA (vimentin). Hyperactive immune response, resulting in the symptoms listed above.

The use of hematopoietic stem cells
The question is how stem cells are used to deal with such an answer. Suppose you also know the unique properties of stem cells, ie, "have the right to divide and give rise to specialized cell types." The notion of a key drug of arthritis, scientists disseminate their research and experiments. We have listed the following steps.

    Healthy cells in the bone marrow (hematopoietic stem cells) were taken from patients (preferably thigh) in a test tube, and then collected in a controlled environment. The patient is under general anesthesia before the incision.
    The method of collecting stem cells is difficult because it depends on the requirement that the donor and treatment. In fact, bone marrow stem cells were separated by centrifugation.

    Some stem cells are washed and concentrated by centrifugation in successive rounds. The concentration step is carried out on their effectiveness to multiply and grow.
    Stem cells are now ready to be implanted in the patient. In the case of arthritis, stem cells are implanted in the affected joints. Inflammatory cells are destroyed by chemotherapy, before the introduction of healthy cells.

Stem cells to regenerate and give birth to healthy cells. This is the main method of treatment with stem cells. However, this process is not as simple as it seems in this list. This is because there are many factors to consider before one. We explained below.

    Stem cells taken from patients in order to remove the complications of graft rejection by antibodies. This technique, known as autologous transplantation.
    Although hematopoietic stem cells can be obtained from a healthy donor (allogeneic) or the same patient (syngeneic transplantation) twins, in which case there is a chance of failure. Thus, the immunosuppressive drugs administered to the patient.
    The method of collecting stem cells known as plasma. This step is very important, because stem cells are mobilized from the resting blood cells in combination with granulocyte colony-stimulating factor (G-CSF) and cyclophosphamide. Both contributed to the rapid proliferation of stem cells.
    The next step is the selection of CD34 + stem cells of the molecule (cluster of differentiation). This marker is a glycoprotein that promotes adhesion of the maternal cells are formed in the bone marrow extracellular matrix. Transplanted stem cells are positively selected only in the joints.
Embryonic stem cell research
Research conducted at the Ukrainian National Medical University used embryonic stem cells for transfer procedures. They found that the control group that suffer from arthritis are common symptoms, including morning stiffness of joints, pyrexia, synovitis, the presence of C-reactive protein and rapid deposition. When the graft is placed in them, all the symptoms began to disappear after about two months. In addition to the use of hematopoietic stem cells and embryonic stem cells, many studies on the use of stem cells as an alternative for the treatment of arthritis. It also provides a report published in the journal Arthritis and Rheumatism, published by the American College of Rheumatology that a woman with rheumatoid arthritis treated with stem cell therapy. If necessary, this allogeneic transplantation and received his sister. He was completely cured of the disease within one year after transplantation. The study also showed that the immunosuppressive drugs completely from the risk of graft-vs.

Benefits of stem cell therapy

    In fact, this is an excellent alternative to traditional surgery such as hip replacement, etc., and the transfer is through a small incision.

    High doses of steroids and anti-inflammatory drugs is stopped when the healthy cells to regenerate the body.

    The biggest advantage of Therapy results are guaranteed. Rheumatoid arthritis can be completely represented by long-term therapy with stem cells.

Although many controversies related to gene therapy, it up higher than negative ones. Clinical trials conducted in patients with rheumatoid order to find the best means of treatment. Nevertheless, the success of detection depends on the reaction of ordinary people against him. There are currently exposed to this type of therapy is really expensive, but considering the benefits and operating expense benefits is established without doubt that in the future.